The cees dekker Diaries
The cees dekker Diaries
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Making use of single-molecule optical and AFM imaging and drive-spectroscopy procedures, we search for to unravel the mechanistic areas of the composition and dynamics of chromosomes. Our exploration passions consist of:
It had been only inside the nineteen nineties even though, when nanotechnology experienced Superior to your level wherever single molecules may be manipulated, that the first experimental units commenced to appear.
Multicolor imaging with the bacterial nucleoid and mobile division proteins with blue, orange, and close to-infrared fluorescent proteins
Given that 2000, Dekker has shifted the leading concentrate of his operate to biophysics exactly where he reports the Attributes of single biomolecules and cells using the equipment of nanotechnology. This change of area was driven by his fascination for that extraordinary functioning of biological molecular constructions, and also because of the long-term viewpoint that lots of appealing discoveries is usually expected Within this area.[5] Existing traces of exploration in his biophysics team are during the parts of:[six]
2012, discovery that nucleoid occlusion underlies the precision of bacterial cell division; and first at any time study with the dynamics DNA supercoils and the discovery of supercoil hopping
Direct immobilization of indigenous yeast iso-one cytochrome c on bare gold: rapidly electron relay to redox enzymes and zeptomole protein-film voltammetry
You are a Christian. If you could make this kind of synthetic mobile, would you be a single step closer to God, or would the role of God have diminished rather once more?
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Knowledge essential procedures regulating the spatial and dynamic organisation with the DNA in Stay cells.
‘The fantastically subtle way by which elements in mother nature operate in no way ceases to amaze me. If we resolve the puzzle of how life arrived into getting, I anticipate that my amazement at the complexity of generation can have elevated and with it my awe for the greatness with the Creator.’
Because 2000 he moved to one-molecule biophysics and nanobiology, with analysis from studies of DNA loop extrusion and supercoiling to DNA translocation by way of nanopores. Much more a short while ago his investigation has focused on learning chromatin structure and mobile division with bacteria on chip, when he can also be seeking to in the end Make synthetic cells from The underside up.
Cees Dekker is Distinguished College Professor at TU Delft. Experienced for a physicist, he pioneered nanotechnology with quite a few discoveries on carbon nanotubes from the nineteen nineties. Due to the fact 2000, he moved to solitary-molecule biophysics and nanobiology. His recent investigation focuses on (i) nanopores for protein sequencing; (ii) chromosome construction, in particular SMC motor protein; and (iii) developing a dwelling artificial cell from lifeless molecules. Dekker is definitely an elected member from the KNAW and fellow towards the APS and the IOP.
2008, initial observation of protein-coated DNA translocation through nanopores; resolved the origin of your electrophoretic drive on DNA in nanopores; learned a big velocity enhance of microtubules in electrical fields; identified an anomalous electro-hydrodynamic orientation ceesdekker of microtubules; and resolved the origin of noise in carbon nanotubes in liquid
2013, controlled shaping of Stay bacterial cells into arbitrary shapes; and discovery of spontaneous fluctuations from the handedness of histone tetrasomes